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. Author manuscript; available in PMC: 2018 Feb 15.
Published in final edited form as: Chem Rev. 2017 May 25;118(3):1069–1091. doi: 10.1021/acs.chemrev.7b00105

Figure 11.

Figure 11

Trimeric arrangement of PRL1 in the crystal structure. (A) Overall structure of the PRL1 trimer in two orientations. In each monomer, the secondary structures are labeled; the P-loop and C-terminal tail are highlighted in red and blue, respectively. (B) Surface representation of the PRL1 trimer. Two dimer interfaces in monomer b are highlighted in purple (ba-interface) and yellow (bc-interface), and all residues involved in these interfaces in monomer b are listed accordingly. The close-up view of key interactions are respectively shown in (C) and (D) for ba- and bc-interface.