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. Author manuscript; available in PMC: 2018 Feb 15.
Published in final edited form as: Chem Rev. 2017 May 25;118(3):1069–1091. doi: 10.1021/acs.chemrev.7b00105

Figure 8.

Figure 8

LS SHP2 mutations reduce SHP2 phosphatase activity by disturbing different step(s) in the catalytic process. In this figure, SHP2 wild-type (gray) and mutant (green) were superimposed onto PTP1B (cyan) structure representing transition state 1 or 2 to show mutation-induced disturbance at each specific step. Residue numbers are shown in blue for PTP1B and black for SHP2. Red dash lines represent mutation induced steric conflicts.