Table 1.

Univariate logistic regression analysis identifying predictors of recurrence in patients achieving early biochemical remission. Remission was defined as cortisol nadir ≤5µg/mL by POD-10. Measures of association are represented as odds ratio with corresponding p-values. Accounting for potential confounding variables of age, gender, BMI and ethnicity, adjusted odds ratio with corresponding p-values are presented.

Variables		OR	95% CI	Std Error	P value	Adj OR	P value
Demographics
	Age	1.023	0.99, 1.06	0.016	0.150
	BMI	1.013	0.95, 1.08	0.031	0.663
	Gender	0.737	0.26, 2.10	0.534	0.568
	White	1.519	0.60, 3.84	0.474	0.378
	Black	0.585	0.18, 1.87	0.594	0.366
	Asian	0.320	0.06, 1.65	0.837	0.173
Perioperative outcomes
	MRI-positive	1.030	0.38, 2.78	0.506	0.954	0.877	0.812
	Visualised intra-operatively	0.664	0.15, 3.00	0.770	0.595	0.683	0.637
	Imaging/resection concordance	3.758	1.17, 12.11	0.597	0.027*	7.010	0.006**
	Pathology positive	1.958	0.61, 6.34	0.600	0.262	2.196	0.238
	Imaging/pathology concordance	2.097	0.85, 5.16	0.460	0.107	1.039	0.074
Cortisol
	0000hr POD-0	0.971	0.94, 1.01	0.018	0.109	0.962	0.068
	1800hr POD-0	0.974	0.94, 1.01	0.017	0.116	0.970	0.135
	0000hr POD-1	0.970	0.94, 1.01	0.017	0.075	0.959	0.061
	0600hr POD-1	0.933	0.89, 0.98	0.026	0.007**	0.904	0.002**
	1200hr POD-1	0.907	0.82, 1.00	0.049	0.043*	0.873	0.040*
	1800hr POD-1	0.889	0.81, 0.98	0.048	0.014*	0.887	0.028*
	1800hr POD-2	0.894	0.78, 1.03	0.072	0.119	0.847	0.072
	0000hr POD-3	1.023	0.89 1.18	0.073	0.752	1.030	0.748
	0600hr POD-3	0.959	0.92, 1.00	0.022	0.062	0.959	0.062
	1200hr POD-3	0.900	0.82, 1.00	0.050*	0.036*	0.882	0.130
	1800hr POD-3	0.981	0.93, 1.04	0.028	0.487	1.010	0.842
	NEPV cortisol	0.931	0.87, 0.99	0.033*	0.031*	0.902	0.039*

Those of statistical signficance are marked with asterisks.

POD = post-operative day, BMI = body mass index, Adj = adjusted, OR = odds ratio, Std error = standard error, P value = probability value.