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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Glia. 2017 Dec 30;66(4):846–861. doi: 10.1002/glia.23288

Figure 6. Differential recovery of OPCs at 3 months post-radiation.

Figure 6

There is an overall effect of radiation exposure (p=0.0019), rostral-caudal location (p<0.0001), and interaction (p=0.0001) on OPCs in female mice (A), and an effect of exposure (p=0.0029), rostral-caudal location (p<0.0001), and the interaction (p<0.0001) in male mice (B). C. PCNA+ proliferative OPCs are reduced after fractionated IR in female mice, where there is a significant effect of exposure (p<0.0001) and rostral-caudal location (p=0.0009) in logit-transformed PCNA+ YFP+/ YFP+ cells. D. Radiation exposure affects the logit-transformed PCNA+ fraction of YFP+ cells in males (p=0.0009). Quantitation was performed across the cortex and hippocampus. n = 4–5 animals/group, 2-way ANOVA with repeated measures, Dunnett’s multiple comparisons test comparing radiation groups to control. Graphs represent mean ± SEM. *: p<0.05 for 0 Gy versus 6× 6 Gy; #: p<0.05 for 0 Gy versus 1× 20 Gy.