Table 3.
Performance of MRE for diagnosing Malignant from Benign Masses in 85 patients, and diagnosing Pancreatic Ductal Adenocarcinoma (PDAC) from Mass-Forming Pancreatitis (MFP) in 67 patients
| Prediction | Malignant vs benign masses | PDAC vs MFP | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| Parameters | Mass stiffness | Stiffness ratio | CA19-9 | Mass stiffness | Stiffness ratio | CA19-9 |
| Cutoff | 2.72kPa | 1.38 | 91 KU/L | 2.72kPa | 1.38 | 91 KU/L |
| AUC | 0.845 (0.751–0.915) | 0.912 (0.830–0.962) | 0.702 (0.593–0.797) | 0.882 (0.780–0.948) | 0.955 (0.875–0.991) | 0.745 (0.624–0.844) |
| Sensitivity (%) | 68.5 (54.4–80.5) | 88.9 (77.4–95.8) | 37.0 (24.3–51.3) | 72.1 (56.3–84.7) | 90.7 (77.9–97.4) | 46.5 (31.2–62.3) |
| Specificity (%) | 93.5 (78.6–99.2) | 87.1 (70.2–96.4) | 96.8 (83.3–99.9) | 95.8 (78.9–99.9) | 95.8 (78.9–99.9) | 95.8 (78.9–99.9) |
| PPV (%) | 94.9 (82.7–99.4) | 92.3 (81.5–97.9) | 95.2 (76.2–99.9) | 96.9 (83.8–99.9) | 97.5 (86.8–99.9) | 95.2 (76.2–99.9) |
| NPV (%) | 63.0 (47.5–76.8) | 81.8 (64.5–93.0) | 46.9 (34.3–59.8) | 65.7 (47.8–80.9) | 85.2 (66.3–95.8) | 50.0 (34.9–65.1) |
| Accuracy (%) | 77.6 | 88.2 | 58.8 | 80.5 | 92.5 | 64.2 |
Cut-off values were selected based on receiver operating characteristic (ROC) analysis with greater stiffness/stiffness ratio in PDAC/malignancy. Numbers in parentheses are the 95% confidence interval. AUC area under the ROC curve; NPV negative predictive value; PPV positive predictive value.