Figure 2.

The Effects of BMI-Associated SNPs across the Sample BMI Distribution

CQR models of BMI-associated SNPs were fitted every fifth percentile of BMI and adjusted for age, age squared, sex, and study. Estimates of the change in BMI (kg/m²) per effect allele (β_CQR) from these models were plotted against the BMI percentile (thick black line) along with the 95% confidence intervals (shaded gray region). The results from OLS models (β_OLS, kg/m² per effect allele, horizontal dashed green line) and the 95% confidence intervals (horizontal dotted green lines) were also plotted for comparison. The change in CQR estimates across BMI percentiles was modeled with MR, and estimates from MR (β_MR, kg/m² per effect allele per BMI percentile, thin magenta line) and the 95% confidence intervals (dotted magenta lines) were plotted. MR analysis detected significant (p < 1.32 × 10⁻³) increases in the effects of these SNPs across the sample BMI distribution.