Table 1.
BMI-Associated SNP Information and Results from OLS Models
| SNP | Gene (OMIM) | Chromosome Position | E/O | PMID | βOLS[95% CI] | p Value |
|---|---|---|---|---|---|---|
| rs1421085 | FTO (610966) | chr16: 53,800,954 | C/T | 17658951 | 0.512 [0.451, 0.572] | 5.88 × 10−62 |
| rs10767664 | BDNF (113505) | chr11: 27,725,986 | A/T | 20935630 | 0.246 [0.172, 0.319] | 5.89 × 10−11 |
| rs11672660 | GIPR (137241) | chr19: 46,180,184 | C/T | 25673413 | 0.234 [0.159, 0.309] | 8.16 × 10−10 |
| rs4788099 | SH2B1 (608937) | chr16: 28,855,727 | G/A | 23001569 | 0.180 [0.113, 0.246] | 1.13 × 10−7 |
| rs7903146 | TCF7L2 (602228) | chr10: 114,758,349 | C/T | 25673413 | 0.167 [0.102, 0.232] | 5.36 × 10−7 |
| rs2075650 | TOMM40 (608061) | chr19: 45,395,619 | A/G | 23001569 | 0.218 [0.131, 0.305] | 9.75 × 10−7 |
| rs11873305 | MC4R (155541) | chr18: 58,049,192 | A/C | 25673413 | 0.384 [0.229, 0.539] | 1.23 × 10−6 |
| rs997295 | MAP2K5 (602520) | chr15: 68,016,343 | T/G | 23001569 | 0.131 [0.070, 0.191] | 2.40 × 10−5 |
| rs3824755 | NT5C2 (600417) | chr10: 104,595,849 | C/G | 25673413 | 0.218 [0.115, 0.321] | 3.32 × 10−5 |
| rs12617233 | FANCL (608111) | chr2: 59,039,998 | C/T | 23001569 | 0.128 [0.067, 0.190] | 4.34 × 10−5 |
| rs6499653 | FTO (610966) | chr16: 53,877,592 | T/C | 25673413 | 0.142 [0.073, 0.211] | 5.19 × 10−5 |
| rs1788826 | NPC1 (607623) | chr18: 21,154,024 | G/A | 25673413 | 0.124 [0.061, 0.186] | 1.08 × 10−4 |
| rs17066846 | MC4R (155541) | chr18: 58,044,818 | G/T | 25673413 | 0.144 [0.068, 0.220] | 2.09 × 10−4 |
| rs6453133 | HMGCR (142910) | chr5: 74,692,776 | A/G | 25673413 | 0.124 [0.058, 0.189] | 2.18 × 10−4 |
| rs739564 | IQCK | chr16: 19,740,237 | A/G | 25673413 | 0.147 [0.067, 0.227] | 2.97 × 10−4 |
| rs2272903 | TFAP2B (601601) | chr6: 50,786,571 | G/A | 23001569 | 0.173 [0.076, 0.270] | 4.77 × 10−4 |
| rs7553158 | TNNI3K (613932) | chr1: 75,005,238 | G/A | 25673413 | 0.102 [0.042, 0.162] | 8.40 × 10−4 |
| rs11570094 | SPI1 (165170) | chr11: 47,359,706 | A/C | 25673413 | 0.107 [0.041, 0.172] | 1.37 × 10−3 |
| rs4946932 | FOXO3 (602681) | chr6: 108,974,746 | C/A | 25673413 | 0.107 [0.041, 0.174] | 1.57 × 10−3 |
| rs2819347 | LMOD1 (602715) | chr1: 201,884,288 | G/C | 25673413 | 0.101 [0.037, 0.165] | 1.89 × 10−3 |
| rs2836754 | ETS2 (164740) | chr21: 40,291,740 | C/T | 25673413 | 0.099 [0.033, 0.164] | 3.20 × 10−3 |
| rs2984618 | TAL1 (187040) | chr1: 47,690,438 | T/G | 25673413 | 0.087 [0.026, 0.148] | 5.17 × 10−3 |
| rs11208662 | LEPR (601007) | chr1: 65,987,164 | C/G | 23563609 | 0.139 [0.037, 0.242] | 7.66 × 10−3 |
| rs6235 | PCSK1 (162150) | chr5: 95,728,898 | G/C | 18604207 | 0.090 [0.023, 0.158] | 8.82 × 10−3 |
| rs9356744 | CDKAL1 (611259) | chr6: 20,685,486 | T/C | 22344219 | 0.071 [0.005, 0.137] | 0.035 |
| rs7988412 | MTIF3 | chr13: 28,000,282 | T/C | 25673413 | 0.090 [0.005, 0.175] | 0.037 |
| rs1780050 | NEXN (613121) | chr1: 78,400,540 | A/C | 25673413 | 0.063 [0.002, 0.124] | 0.042 |
| rs526134 | USP37 | chr2: 219,402,371 | G/A | 25673413 | 0.066 [0.000, 0.132] | 0.049 |
| rs980828 | NOS1AP (605551) | chr1: 162,306,415 | G/T | 25133637 | 0.050 [−0.010, 0.110] | 0.100 |
| rs17001561 | SCARB2 | chr4: 77,096,118 | A/G | 25673413 | 0.070 [−0.017, 0.157] | 0.113 |
| rs6232 | PCSK1 (162150) | chr5: 95,751,785 | C/T | 18604207 | 0.095 [−0.041, 0.232] | 0.172 |
| rs749767 | KAT8 (609912) | chr16: 31,124,407 | A/G | 25673413 | 0.042 [−0.022, 0.105] | 0.199 |
| rs1211166 | NTRK2 (600456) | chr9: 87,285,992 | A/G | 23001569 | 0.041 [−0.034, 0.116] | 0.289 |
| rs2535633 | ITIH4 (600564) | chr3: 52,859,630 | G/C | 24861553 | 0.024 [−0.037, 0.085] | 0.437 |
| rs10144353 | PRKCH (605437) | chr14: 61,911,157 | T/C | 23563609 | 0.044 [−0.067, 0.155] | 0.441 |
| rs1561288 | ADCY3 (600291) | chr2: 25,369,002 | C/T | 23669352 | 0.024 [−0.047, 0.095] | 0.507 |
| rs2283228 | KCNQ1 (607542) | chr11: 2,849,530 | C/A | 24861553 | −0.037 [−0.159, 0.085] | 0.550 |
37 BMI-predisposing SNPs were selected for analysis. The effect and other (E and O, respectively) alleles were based on original discovery studies (PMID), and SNPs were coded by BMI-increasing or obesity-predisposing alleles. The indicated positions are based on GRCh37, and all alleles are on the positive strand. The association between these SNPs and BMI was assessed by OLS models that were adjusted for age, age squared, sex, and study. βOLS is the effect size (kg/m2 per effect allele), and 95% CIs are the 95% confidence intervals.