Table 1.
Dissection of Genetic Covariance between LOAD and ALS
| Annotation | Category | Covariance | p Value |
|---|---|---|---|
| Non-stratified | GNOVA | 0.016 (0.004) | ∗2.0 × 10−4 |
| LDSC | 0.012 (0.007) | 0.075a | |
| GenoCanyon | functional | 0.016 (0.004) | ∗8.2 × 10−5 |
| non-functional | 0.003 (0.004) | 0.377 | |
| MAF | Q1 | −0.001 (0.003) | 0.842 |
| Q2 | 0.003 (0.004) | 0.361 | |
| Q3 | 0.004 (0.004) | 0.327 | |
| Q4 | 0.008 (0.003) | ∗0.005 |
Numbers in parentheses indicate standard errors. Significant p values after adjusting for multiple testing within each section are indicated by an asterisk (∗).
a
p value in LDSC was calculated from genetic correlation instead of genetic covariance.