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. 2017 Nov 27;17(4):141–145. doi: 10.1016/j.tjem.2017.10.001

Table 1.

Diagnostic criteria for NMS.

Criteria Characteristics At least
History of drug use
  • -

    Use of one antipsychotic

  • -

    Use of one dopamine antagonist

  • -

    Recent termination of treatment with one dopamine agonist

 1
Major criteria
  • -

    Hyperthermia (37.5° or above)

  • -

    Muscular rigidity,

  • -

    Creatine kinase (CK) levels over 3 times above normal

 2
Minor criteria
  • -

    Altered mental state,

  • -

    Extrapyramidal findings, Autonomic instability,

  • -

    Respiration problems,

  • -

    Leukocytosis

 4