Figure 3.

15q13.3 CNV NPCs Have Correlative Gene Expression by qPCR

Control NPCs are shown in gray, duplication NPCs are in blue, and deletion NPCs are in red. All groups were compared using a one-way ANOVA.

(A) CHRNA7 is fully duplicated for all sizes of 15q13.3 gains (n = 3 clones, 3 individuals).

(B) The expression of OTUD7A in small D-CHRNA7-LCR/BP5 gains (n = 1 clone, 1 individual) is not altered as compared to controls (n = 3 clones, 3 individuals), while its expression is appropriately up- or downregulated in larger duplications (n = 2 clones, 2 individuals) and deletions (n = 3 clones, 3 individuals), respectively.

^∗∗∗∗p < 0.0001; ns, not significant; BP, breakpoint. Error bars indicate standard error.