Table 1.
2q13 | 2q31.1 | 3q23 | 6q24.2 | 10p12.2 | 14q13.1 | |
---|---|---|---|---|---|---|
Gene candidate(s) | EDAR | SP5 | MRPS22, FOXL2 | ADGRG6 (GPR126) | KIAA1217, ARHGAP21 | PAX9, NKX2-8 |
Lead SNP | rs3827760 | rs6756973 | rs9866054 | rs58122955 | rs7096127 | rs1950357 |
Base position | 109,513,601 | 171,542,573 | 138,997,688 | 142,921,276 | 24,506,439 | 37,209,698 |
Functional position | missense | intronic | intergenic | intronic | intronic | intronic |
Data source | genotyped | imputed | genotyped | imputed | imputed | imputed |
Minor/major alleles | G/A | C/G | A/G | A/G | C/T | C/A |
European American | ||||||
MAF | 0.015 | 0.413 | 0.257 | 0.223 | 0.451 | 0.386 |
Beta | 0.028 | 0.073 | −0.041 | 0.119 | −0.034 | 0.086 |
SE | 0.081 | 0.020 | 0.022 | 0.023 | 0.019 | 0.020 |
p value | 0.733 | 1.84 × 10−4 | 0.059 | 2.78 × 10−7 | 0.077 | 2.40 × 10−5 |
Latin American | ||||||
MAF | 0.404 | 0.661 | 0.550 | 0.185 | 0.490 | 0.359 |
Beta | 0.062 | 0.088 | −0.025 | 0.067 | −0.043 | 0.027 |
SE | 0.012 | 0.011 | 0.011 | 0.013 | 0.010 | 0.010 |
p value | 7.67 × 10−8 | 7.29 × 10−16 | 0.019 | 2.34 × 10−7 | 2.06 × 10−5 | 9.41 × 10−3 |
Chinese | ||||||
MAF | 0.946 | 0.419 | 0.429 | 0.267 | 0.303 | 0.295 |
Beta | 0.129 | 0.101 | −0.128 | 0.051 | −0.052 | 0.065 |
SE | 0.032 | 0.015 | 0.015 | 0.017 | 0.016 | 0.016 |
p value | 5.66 × 10−5 | 9.84 × 10−12 | 2.60 × 10−18 | 0.002 | 0.001 | 8.04 × 10−5 |
Meta-analysis for Rater-Scored Cohorts | ||||||
p value | 6.65 × 10−10 | 1.13 × 10−28 | 5.27 × 10−13 | 2.49 × 10−14 | 2.44 × 10−8 | 4.82 × 10−9 |
23andMe | ||||||
MAF | 0.007 | 0.410 | 0.249 | 0.238 | 0.451 | 0.389 |
OR | 1.490 | 1.270 | 0.837 | 1.335 | 0.813 | 1.237 |
CI | (1.299, 1.709) | (1.238, 1.303) | (0.813, 0.862) | (1.296, 1.375) | (0.793, 0.834) | (1.206, 1.269) |
p value | 2.04 × 10−8 | 4.90 × 10−76 | 4.42 × 10−33 | 3.31 × 10−87 | 8.48 × 10−59 | 8.26 × 10−59 |
Meta-analysis for All Cohorts | ||||||
p value | 1.16 × 10−13 | 1.65 × 10−99 | 4.78 × 10−43 | 7.64 × 10−100 | 1.56 × 10−65 | 2.85 × 10−66 |
Abbreviations are as follows: MAF, minor allele frequency; SE, standard error of the beta-coefficient; OR, odds ratio; and CI, 95% confidence interval of the odds ratio.