Table 1.

Evidence of Association for the Lead SNP in Each Significant (p < 5 × 10⁻⁸) Locus Nominated in the Meta-analysis across the Rater-Scored Cohorts

	2q13	2q31.1	3q23	6q24.2	10p12.2	14q13.1
Gene candidate(s)	EDAR	SP5	MRPS22, FOXL2	ADGRG6 (GPR126)	KIAA1217, ARHGAP21	PAX9, NKX2-8
Lead SNP	rs3827760	rs6756973	rs9866054	rs58122955	rs7096127	rs1950357
Base position	109,513,601	171,542,573	138,997,688	142,921,276	24,506,439	37,209,698
Functional position	missense	intronic	intergenic	intronic	intronic	intronic
Data source	genotyped	imputed	genotyped	imputed	imputed	imputed
Minor/major alleles	G/A	C/G	A/G	A/G	C/T	C/A
European American
MAF	0.015	0.413	0.257	0.223	0.451	0.386
Beta	0.028	0.073	−0.041	0.119	−0.034	0.086
SE	0.081	0.020	0.022	0.023	0.019	0.020
p value	0.733	1.84 × 10−4	0.059	2.78 × 10−7	0.077	2.40 × 10−5
Latin American
MAF	0.404	0.661	0.550	0.185	0.490	0.359
Beta	0.062	0.088	−0.025	0.067	−0.043	0.027
SE	0.012	0.011	0.011	0.013	0.010	0.010
p value	7.67 × 10−8	7.29 × 10−16	0.019	2.34 × 10−7	2.06 × 10−5	9.41 × 10−3
Chinese
MAF	0.946	0.419	0.429	0.267	0.303	0.295
Beta	0.129	0.101	−0.128	0.051	−0.052	0.065
SE	0.032	0.015	0.015	0.017	0.016	0.016
p value	5.66 × 10−5	9.84 × 10−12	2.60 × 10−18	0.002	0.001	8.04 × 10−5
Meta-analysis for Rater-Scored Cohorts
p value	6.65 × 10−10	1.13 × 10−28	5.27 × 10−13	2.49 × 10−14	2.44 × 10−8	4.82 × 10−9
23andMe
MAF	0.007	0.410	0.249	0.238	0.451	0.389
OR	1.490	1.270	0.837	1.335	0.813	1.237
CI	(1.299, 1.709)	(1.238, 1.303)	(0.813, 0.862)	(1.296, 1.375)	(0.793, 0.834)	(1.206, 1.269)
p value	2.04 × 10−8	4.90 × 10−76	4.42 × 10−33	3.31 × 10−87	8.48 × 10−59	8.26 × 10−59
Meta-analysis for All Cohorts
p value	1.16 × 10−13	1.65 × 10−99	4.78 × 10−43	7.64 × 10−100	1.56 × 10−65	2.85 × 10−66

Abbreviations are as follows: MAF, minor allele frequency; SE, standard error of the beta-coefficient; OR, odds ratio; and CI, 95% confidence interval of the odds ratio.