Covalent structures of (A) mutacin 1140, (B) salivaricin A2, (C) nukacin ISK-1, and (D) mersacidin. The lanthionine rings are labeled as rings A, B, C, and D for mutacin 1140 and mersacidin and as rings A, B, and C for salivaricin A2 and nukacin ISK-1. Dehydrated residues from serine and threonine are labeled as Dha and Dhb, respectively. (Methyl-)lanthionine is formed between a cysteine and a dehydrated residue.