TABLE 3.
MICs and MLCs (μg/ml) for mutacin 1140 and salivaricin A2
| Bacterial strain | Mutacin 1140 |
Salivaricin A2 |
||
|---|---|---|---|---|
| MIC (μg/ml) | MLC (μg/ml) | MIC (μg/ml) | MLC (μg/ml) | |
| M. luteus ATCC 10240 | 0.0625 | 0.0625 | 2 | 2 |
| C. accolens ATCC 49725 | 0.125 | 0.125 | 8 | 8 |
| C. accolens KPL 1818 | 0.125 | 0.125 | 16 | 32 |
| C. accolens KPL 2060 | 0.0625 | 0.0625 | 8 | 16 |
| C. accolens KPL 2061 | 0.25 | 0.25 | 16 | 32 |
| C. pseudodiphtheriticum KPL 1989 | 0.125 | 0.125 | 8 | 8 |
| C. striatum KPL 1959 | 0.5 | 1 | 32 | 32 |
| C. accolens KPL 1855 | 1 | 1 | 16 | 32 |
| S. pneumoniae ATCC 27336 | 0.5 | 0.5 | 32 | 32 |
| S. pneumoniae AI8a | 1 | 1 | 32 | 32 |
| S. pneumoniae AI11a | 1 | 1 | 16 | 16 |
| S. pneumoniae AI14a | 0.125 | 0.125 | 32 | 32 |
| S. pneumoniae AI6 | 1 | 1 | 128 | 128 |
| S. pneumoniae AI7 | 0.25 | 0.25 | 128 | 128 |
| S. mutans JH1140 | 8 | 8 | >128 | >128 |
| S. salivarius HS0302 | 0.5 | 0.5 | 64 | 128 |
| B. subtilis PY79 | 8 | 8 | >128 | >128 |
| B. megaterium ATCC 14581 | 8 | 8 | >128 | >128 |
| S. epidermidis ERIN 30713 | 4 | 8 | >128 | >128 |
| S. aureus ATCC 25923 | 4 | 4 | >128 | >128 |
| E. faecalis ERIN 30002 | 16 | 32 | >128 | >128 |
a
MICs for the S. pneumoniae strains were tested in the presence of 5% human blood to promote growth.