Table 3.

Changes in collagen percentage areas and liver stiffness measurements between regression and progression groups by Ishak staging and qFibrosis.

	Regression by Ishak (n = 69)	Stable by Ishak (n = 84)			Progression by Ishak (n = 9)
		Regression by qFibrosis	Stable by qFibrosis	Progression by qFibrosis
No. (%)	69 (42.6)	40 (24.7)	29 (17.9)	15 (9.3)	9 (5.6)
**P-I-R 78w, n (%)
P	0	1 (3.1)	3 (15.8)	2 (20.0)	2 (33.3)
I	6 (18.2)	8 (25.0)	5 (26.3)	2 (20.0)	2 (33.3)
R	27 (81.8)	23 (71.9)	11 (57.9)	6 (60.0)	2 (33.3)
Δ LSM/Baseline, %	−44 (−63, −12)	−46 (−63, −19)	−20 (−45,+11)	−27 (−39,+1)	−17 (−36,+4)
Δ Collagen area
Δ Total-CPA	−1.33 (−3.96, −0.42)	−2.63 (−4.31, −1.30)	−0.05 (−0.55,+0.38)	+0.74 (+0.59,+1.82)	+1.13 (+0.52,+3.30)
Δ Portal-CPA	−0.24 (−0.74, 0)	−0.17 (−0.80,+0.13)	−0.21 (−0.47,+0.18)	−0.14 (−0.40,+0.45)	+0.01 (−0.10,+2.32)
Δ Septal-CPA	−0.58 (−2.10, −0.16)	−1.31 (−2.45, −0.64)	+0.17 (−0.07,+0.44)	+0.66 (+0.53,+1.74)	+0.29 (−0.21,+1.22)
Δ Fibrillar-CPA	−0.44 (−1.24, −0.09)	−0.96 (−1.42, −0.46)	+0.04 (−0.07,+0.19)	+0.26 (+0.14,+0.57)	+0.17 (−0.05,+0.56)

^*P < 0.05 in Δ LSM/Baseline, Total-CPA, Septal-CPA and Fibrillar-CPA; ^#P > 0.05 in Δ LSM/Baseline and Portal-CPA; ^##P > 0.05 in all parameters; ^**P-I-R, predominantly progressive, indeterminate, predominantly regressive, only applicable for Ishak ≥ 3.

LSM, liver stiffness measurement; CPA, collagen percentage area.