Table 2.
Improvement in risk prediction when adding more component scores.
| Base score | Enhanced score | Net Reclassification Improvement | Integrated Discrimination Improvement | Improvement in AUROC | p value* |
|---|---|---|---|---|---|
| GRS24 | GRS24 + GRS68 = GRS92 | 0.282 | 0.027 | 0.0484 | <0.001 |
| GRS92 | GRS92 + NMRFS | 0.236 | 0.015 | 0.0141 | 0.01 |
| GRS92 | GRS92 + MRFS | 0.072 | 0.003 | 0.0024 | 0.37 |
| NMRFS | NMRFS + MRFS = RFS | 0.017 | 0.000 | −0.0013 | 0.18 |
*p value for the improvement in AUROC.
GRS24: Genetic Risk Score with 24 SNPs.
GRS68: Genetic Risk Score with 68 SNPs.
GRS92: Genetic Risk Score with 92 SNPs.
NMRFS: Non-modifiable Risk Factor Score.
MRFS: Modifiable Risk Factor Score.
RFS: Risk Factor Score.