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. 2018 Feb 14;8:3013. doi: 10.1038/s41598-018-21273-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Depletion of Lysozyme M positive cells leads to faster thrombus resolution in IVC ligated mice. (A) Scheme of experimental setup. US, ultrasound. Red boxes, DTX high dose. Grey boxes, DTX low dose. Each box represents 1day. (B) Sizes determined by high frequency ultrasound calculated as percentage at day 1 after subtotal ligation, of thrombi in LysM and LysM^iDTR group at indicated time points after subtotal ligation. Mean ± SEM; two-way ANOVA/Bonferroni post hoc test; n = 8; *p ≤ 0.05; **p ≤ 0.01. (C) Flow cytometric analysis of cell count of CD45⁺ cells/mg thrombus and neutrophils and monocytes displayed as percentage of CD45⁺ cells (day 2 post subtotal ligation) in thrombus tissue of LysM^iDTR mice compared to LysM controls. (D) mRNA expression levels of ccl-2, il-4 and il-10 in thrombus material. Mean ± SEM; t-test; n = 5–8; *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001. HFUS, high frequency ultrasound.