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. 2018 Feb 14;8:3013. doi: 10.1038/s41598-018-21273-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Critical role of T-bet in bone marrow-derived cells for thrombus resolution. (A) Thrombus sizes determined by high frequency ultrasound calculated as percentage at day 2, of thrombi in irradiated C57BL/6 wild type mice (CD45.1⁺ Ly5.1) mice transplanted with bone marrow of Tbx21^−/− mice (Tbx21^−/− → wt) compared to irradiated Tbx21^−/− mice transplanted with wild type bone marrow (wt→ Tbx21^−/− mice) at indicated time points following IVC stenosis. Mean ± SEM; two-way ANOVA/Bonferroni post hoc test; n = 3–4; **p ≤ 0.01; ****p ≤ 0.0001. (B) Analysis of il-12p40 and ccl-2 mRNA expression in thrombus material. Mean ± SEM. n = 3–4 animals per group; t-test; *p ≤ 0.05. (C) Histological staining (Carstairs staining) and immunohistochemistry (CD31 staining) of IVCs 14d after subtotal ligation. Magnification x10. Summary of the quantitative analysis, results in mean ± SEM. n = 3–4 animals per group; t-test; *p ≤ 0.05.