Table 3.

Mean (±SE) and GLM outcomes of dependent variables of the POMS; 1 = POMS baseline measurement, 2 = POMS measurement before cognitive tests (peak drug) and 3 = POMS measurement after cognitive tests (end of test day); p = – depicts statistical insignificance at p < 0.05

Mood scales	Mean (±SE) mood scales					Main and interaction effect GLM RM ANOVA
	PT	PLA	PLA	KET	KET	PT		T		PT × T
	T	PLA	MDMA	PLA	MDMA	F 1, 19	p	F 1, 19	p	F 1, 19	p
Anxiety	1	2.7 (0.3)	2.8 (0.3)	2.5 (0.3)	3.0 (0.5)	0.94	–	0.36	–	0.50	–
	2	2.0 (0.3)	4.8 (0.9)	2.4 (0.3)	4.7 (0.6)	0.08	0.00	32.42	0.00	0.21	–
	3	2.5 (0.2)	5.8 (0.7)	3.0 (0.3)	3.2 (0.4)	9.73	0.00	18.62	0.00	13.73	0.001
Depression	1	0.1 (0.1)	0.2 (0.1)	0.2 (0.2)	0.4 (0.3)	0.65	–	0.43	–	0.07	–
	2	0.2 (0.2)	0.1 (0.1)	0.4 (0.2)	0.6 (0.3)	2.58	–	0.00	–	0.61	–
	3	0.4 (0.1)	0.5 (0.2)	0.5 (0.2)	0.2 (0.1)	0.15	–	0.18	–	1.75	–
Anger	1	0.7 (0.2)	0.8 (0.2)	1.2 (0.3)	0.9 (0.3)	2.65	–	0.12	–	0.56	–
	2	0.8 (0.3)	0.9 (0.2)	0.5 (0.2)	0.8 (0.3)	0.96	–	2.49	–	0.80	–
	3	0.9 (0.3)	1.2 (0.3)	0.6 (0.0)	0.4 (0.2)	8.89	–	0.18	–	1.77	–
Vigour	1	11.2 (1.1)	12.2 (1.2)	11.9 (1.3)	11.7 (1.1)	0.04	–	0.41	–	0.80	–
	2	10.0 (1.2)	13.7 (1.3)	6.5 (1.1)	11.4 (1.7)	9.09	0.001	16.72	0.001	0.41	–
	3	9.4 (1.2)	13.8 (1.4)	6.10 (0.8)	9.0 (1.4)	34.10	0.00	18.54	0.00	2.37	–
Fatigue	1	1.3 (0.5)	1.4 (0.4)	1.4 (0.4)	1.9 (0.6)	0.85	–	0.64	–	0.29	–
	2	2.1 (0.6)	1.0 (0.3)	6.7 (1.4)	4.5 (1.5)	10.69	0.03	5.73	0.03	0.44	–
	3	4.3 (1.3)	1.7 (1.2)	7.4 (1.5)	5.3 (1.2)	18.27	0.04	4.79	0.04	0.10	–
Confusion	1	3.1 (0.2)	3.6 (0.4)	3.3 (0.3)	3.4 (0.6)	0.01	–	0.89	–	0.36	–
	2	3.7 (0.33)	4.7 (0.5)	5.1 (0.5)	7.2 (0.9)	9.51	0.01	7.43	0.01	1.92	–
	3	4.7 (0.6)	6.4 (0.6)	6.1 (0.4)	7.6 (0.9)	17.51	0.03	5.87	0.03	0.05	–
Friendliness	1	16.8 (1.2)	17.5 (1.4)	17.3 (1.6)	18.0 (1.2)	0.56	–	0.82	–	0.00	–
	2	15.9 (1.4)	16.7 (1.8)	14.6 (1.4)	16.6 (1.5)	0.66	–	2.93	–	0.73	–
	3	15.2 (1.4)	18.4 (1.5)	13.4 (1.6)	15.9 (1.5)	7.66	0.006	9.58	0.006	0.18	–
Elation	1	10.4 (0.8)	11.2 (0.8)	10.9 (1.0)	11.5 (0.8)	0.86	–	2.02	–	0.04	–
	2	10.0 (1.0)	12.6 (1.1)	8.4 (0.7)	11.3 (1.3)	4.19	0.005	9.92	0.005	0.06	–
	3	8.6 (0.9)	13.3 (1.0)	7.4 (1.0)	10.2 (1.0)	12.26	0.000	25.28	0.00	4.87	0.04
Arousal	1	9.5 (1.5)	10.0 (1.4)	9.6 (1.6)	9.4 (1.6)	0.05	–	0.02	–	0.13	–
	2	6.1 (1.5)	12.8 (1.8)	−2.8 (2.2)	4.3 (3.5)	9.30	0.001	14.30	0.001	0.01	–
	3	3.0 (2.3)	11.5 (2.5)	−4.4 (1.9)	−0.8 (2.6)	39.07	0.004	10.98	0.004	6.49	0.02
Positive mood	1	10.3 (0.9)	11.0 (0.9)	10.7 (1.0)	11.1 (1.0)	0.28	–	0.79	–	0.07	–
	2	9.7 (1.0)	12.5 (1.1)	8.0 (0.8)	10.7 (1.4)	4.49	0.007	8.97	0.007	0.00	–
	3	8.2 (1.0)	12.8 (1.0)	6.9 (1.0)	9.9 (1.0)	7.55	0.00	23.91	0.00	3.37	–