Table 1.
Natural rubber latex allergens
| Allergen | Hevea brasiliensis protein | Clinical relevance |
|---|---|---|
| Hev b 1 | Rubber elongation factor | Major allergen in SB |
| Hev b 2 | β-1,3-Glucanase | Uncertain† |
| Hev b 3 | Small rubber particle proteins | Major allergen in SB |
| Hev b 4 | Lecithinase homolog | Minor allergen† |
| Hev b 5 | Acidic structural protein | Major allergen in HCW and important in SB |
| Hev b 6.01/6.02 | Prohevein/hevein | Major allergen in HCW |
| Hev b 7 | Patatin-like protein (esterase) from latex-B- and C-serum | Minor allergen |
| Hev b 8 | Profilin (actin-binding protein) | Minor allergen |
| Hev b 9 | Enolase | Minor allergen |
| Hev b 10 | Manganese superoxide dismutase (MnSOD) | Minor allergen |
| Hev b 11 | Class I chitinase | Minor allergen |
| Hev b 12 | Non-specific lipid transfer protein type 1 (nsLTP1) | Minor allergen |
| Hev b 13 | Esterase | Uncertain† |
| Hev b 14 | Hevamine | Minor allergen† |
| Hev b 15 | Serine protease inhibitor | Minor allergen |
Hev b Hevea brasiliensis, SB spina bifida patients, HCW health care workers
†Not available in recombinant form