Table 3.

Genes that affect sensitivity to JG-98 sorted according to major pathways.

Major Pathway	Protector shRNA	Sensitizing shRNA
Proteasome		PSMA1 PSMA2 PSMA3 PSMA6 PSMA7 PSMB2 PSMB4 PSMB6 PSMC1 PSMC2 PSMC3* PSMC6* PSMD1 PSMD11** PSMD12** PSMD2** PSMD3 PSMD6** PSMD8** PSMF1**
RNApol		POLR2A POLR2B POLR2D POLR2F POLR2I*
TGF	FNTA* SMAD2* TGFBR1*	USP9X STRAP
WNT	GSK3A*	FZD3* FZD4* FZD7* FZD8* FGF8* TCF7L1*
Golgi	ARFGEF2*	ARF1* ARFGAP3*
Cullin	c-myc*	SKP1** RBX1* Fbxw7* P21* P27*
Translation initiation		EIF1AX EIF1AY* EIF2B5 EIF2S2* EIF3A EIF4BP1**

No * - Genes identified in both MCF7 and MDA-MB231 cells.

^*Genes identified only in MCF7 cells.

^**Genes identified only in MDA-MB231 cells.