Table 2.

PoOxE effects for cleft palate–only example haplotypes

rs2964447‐rs2964137‐rs6868526, ICE1
Haplotype	Stratum	${\text{RR}}_M$	${\text{RR}}_F$	${\text{RR}}_M/{\text{RR}}_F$
T‐G‐C	${\text{RR}}_{\text{S}}$	1.99	0.49	4.04 (1.75, 9.25)
	${\text{RR}}_{\text{NS}}$	0.52	1.04	0.50 (0.31, 0.82)
	${\text{RR}}_{\text{S}}/{\text{RR}}_{\text{NS}}$	3.79 (1.74, 8.22)	0.47 (0.21, 1.05)	7.98 (3.07, 20.77)
T‐G‐G	${\text{RR}}_{\text{S}}$	1.30	0.24	5.35 (1.51, 18.19)
	${\text{RR}}_{\text{NS}}$	0.68	1.30	0.52 (0.29, 0.96)
	${\text{RR}}_{\text{S}}/{\text{RR}}_{\text{NS}}$	1.89 (0.70, 5.07)	0.19 (0.06, 0.62)	10.13 (2.55, 40.19)

‐Reference haplotype: A‐C‐C

‐Overall haplotype frequencies: A‐C‐C 0.48; T‐G‐C 0.36; T‐G‐G 0.16; Europeans only

‐${\text{RR}}_M$ and ${\text{RR}}_F$ are the relative risks depending on parental origin.

‐${\text{RR}}_{\text{NS}}$ and ${\text{RR}}_S$ are the relative risks depending on exposure status (nonsmokers or smokers)