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. 2017 Nov 6;142(5):968–975. doi: 10.1002/ijc.31117

Figure 2.

Figure 2

4SC‐202 inhibits HH/GLI signaling by targeting class I HDACs rather than LSD1. (a) Summary of inhibitors used for chemical perturbations and their molecular targets. (b) qPCR analysis of GLI1 mRNA expression in SAG‐stimulated Daoy cells in response to increasing concentrations of the LSD1 blocker OG‐L002. (c) GLI1 mRNA expression analysis in SAG‐induced or control‐treated Daoy cells transfected with control siRNA (siControl) or siRNA against LSD1 (siLSD1). (d, e) qPCR analysis of GLI1 (d) and HHIP (e) mRNA expression in SAG‐stimulated Daoy cells in response to the HDAC1/2/3 inhibitor entinostat. (f) GLI1 mRNA expression in Daoy cells treated with the FDA‐approved pan‐HDAC inhibitor SAHA (vorinostat).