Table 2.
Pharmacokinetic parameters of GE phenolics in the tumor isolated on day 7 following daily oral administration of GE in nude mice (dose: 250 mg/kg, n = 3 per time point, mean ± SE).
| Analyte | Free/Conjugate | Pharmacokinetic Parameters | ||
|---|---|---|---|---|
| Tmax (h) | Cmax (ng/mL) | AUClast (ng.h/mL) | ||
| 6G | F | 0.5 | 96.79 ± 3.24 | 93.66 ± 4.75 |
| C | 1.0 | 8.24 ± 1.11 | 29.00 ± 4.41 | |
| Ratio c/f | — | 0.085 | 0.31 | |
| 8G | F | 0.5 | 22.58 ± 1.42 | 22.33 ± 0.83 |
| C | 0.5 | 2.92 ± 1.71 | 10.25 ± 2.98 | |
| Ratio c/f | — | 0.13 | 0.46 | |
| 10G | F | 0.5 | 15.78 ± 0.94 | 25.87 ± 2.63 |
| C | 0.25 | 3.88 ± 0.93 | 5.68 ± 0.93 | |
| Ratio c/f | — | 0.25 | 0.22 | |
| 6S | F | 0.25 | 3.67 ± 0.30 | 2.89 ± 0.18 |
| C | 2.0 | 1.63 ± 0.20 | 27.66 ± 8.72 | |
| Ratio c/f | — | 0.44 | 9.57 | |
Tmax: time to reach peak plasma concentration; Cmax: peak plasma concentration; AUClast: area under the curve; SE: standard error; f: free form; c: conjugated form (glucuronide).