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. 2018 Feb 14;8:3056. doi: 10.1038/s41598-018-21125-2

Table 2.

Pharmacokinetic parameters of GE phenolics in the tumor isolated on day 7 following daily oral administration of GE in nude mice (dose: 250 mg/kg, n = 3 per time point, mean ± SE).

Analyte Free/Conjugate Pharmacokinetic Parameters
Tmax (h) Cmax (ng/mL) AUClast (ng.h/mL)
6G F 0.5 96.79 ± 3.24 93.66 ± 4.75
C 1.0 8.24 ± 1.11 29.00 ± 4.41
Ratio c/f 0.085 0.31
8G F 0.5 22.58 ± 1.42 22.33 ± 0.83
C 0.5 2.92 ± 1.71 10.25 ± 2.98
Ratio c/f 0.13 0.46
10G F 0.5 15.78 ± 0.94 25.87 ± 2.63
C 0.25 3.88 ± 0.93 5.68 ± 0.93
Ratio c/f 0.25 0.22
6S F 0.25 3.67 ± 0.30 2.89 ± 0.18
C 2.0 1.63 ± 0.20 27.66 ± 8.72
Ratio c/f 0.44 9.57

Tmax: time to reach peak plasma concentration; Cmax: peak plasma concentration; AUClast: area under the curve; SE: standard error; f: free form; c: conjugated form (glucuronide).