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. 2018 Feb 14;9:677. doi: 10.1038/s41467-018-03098-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Gross chromosomal hyper-rearrangements mediated by sister-chromatid bridging in 53BP1-depleted cancer cells. a Formation of new chromosome 16 and 7 derivatives in HeLa 53BP1^hypo and 53BP1Δ clones. Left panels: whole chromosome 16 painting revealing 16p arm deletion and arm/centromeric translocations in HeLa b9 (53BP1^hypo) cells. Middle panels: 16q deletions and arm/centromeric translocations in HeLa B2 (53BP1^hypo) cells; Isochromosome 16q formation in HeLa b15 (53BP1^hypo) cells. Right panels: whole chromosome 7 painting revealing centromeric translocation in HeLa D4 (53BP1Δ) cells and arm deletion and centromeric translocation in HeLa B2 (53BP1^hypo) cells. b Ideogram of human chromosome 16, marking the positions of FISH probes used in Fig. 6c–f. c 16q distal arm deletion, centromeric translocation and 16p isochromosome formation was identified in HeLa B2 (53BP1^hypo) populations with the indicated percentages. d 16p whole-arm deletion, 16q whole-arm translocation and 16q distal-arm translocation were detected in HeLa b9 (53BP1^hypo) populations with the indicated percentages. e 16q isochromosome formation was detected in HeLa b15 (53BP1^hypo) populations with the indicated percentages. f Normal chromosome 16 showing both p-arm and q-arm is maintained in all HeLa cells