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. 2018 Jan 9;37(4):e97840. doi: 10.15252/embj.201797840

Figure 4. The WD domain of ATG16L1 is essential for LC3‐associated phagocytosis and other non‐canonical autophagy‐dependent processes.

Figure 4

  1. Confocal images of GFP‐LC3 in ATG16L1‐complemented MEF cells phagocytosing red‐labelled apoptotic cells. Scale bar: 10 μm.
  2. Quantification of GFP‐LC3 recruitment to apoptotic corpse‐containing phagosomes in (A). Twenty phagosomes were counted per experiment.
  3. Confocal images of red dextran‐positive macropinosomes ATG16L1 complimented MEF cells. Cropped images show macropinosomes. Scale bar: 10 μm.
  4. Confocal images of GFP‐LC3 in ATG16L1‐complimented MEF cells treated with VacA toxin (10 μM, 4 h). Scale bar: 10 μm.
Data information: In (B), data are presented as mean ± SEM from three separate experiments. ****P < 0.0001 (Student's t‐test).