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. Author manuscript; available in PMC: 2018 Feb 15.
Published in final edited form as: Leuk Lymphoma. 2016 Jun 27;57(11):2489–2498. doi: 10.1080/10428194.2016.1195500

Figure 2.

Figure 2

Schematic representation of the MUC1-C subunit. MUC1-C consists of a 58 aa non-shed extracellular domain (ED), a 28 aa transmembrane domain (TM) and a 72 aa cytoplasmic domain (CD). The MUC1-C cytoplasmic domain contains a CQC motif that is necessary for MUC1-C homodimerization, localization to the nucleus and oncogenic function. The MUC1-C CQC motif is the target of the GO-203 inhibitor. Highlighted are selected phosphorylation sites and binding regions for activation of the IKK → NF-kB p65 and the WNT/b-catenin/TCF4 pathways that promote the malignant phenotype. DNMT: DNA methyltransferase; TSG: tumor suppressor gene.