Table 2.
Anti-leishmanial (IC50 ±SD) and cytotoxic activity (CC50 ±SD) of essentials oils, some of their components and the positive controls
| Anti-leishmanial activity – promastigotes (L. mexicana mexicana) | Cytotoxicity -CHO | Selectivity index | |
|---|---|---|---|
| Samples | IC50 (μg/ml) ± SD | CC50 (μg/ml) ± SD | CHO/Lmm |
| LEO 2013 | 16.69±0.35c | 81.20±1.59d | 4.86 |
| SEO 2013 | 16.00±0.56c | 49.64±8.56c | 3.10 |
| LSEO 2013 | 6.48±0.44b | 27.79±3.73b | 4.29 |
| LEO 2015 | 19.44±1.00c | 80.65±1.60d | 4.15 |
| SEO 2015 | 50.28±2.13d | 82.56±5.51d | 1.64 |
| LSEO 2015 | 61.79±5.05e | 79.06±0.80d | 1.28 |
| R- (+)-limonene | 16.59±0.35c | 29.65±0.78b | 1.79 |
| S- (-)-limonene | >100 | 75.89±0.88d | - |
| 1-octanol | >100 | >100 | - |
| linalool | >100 | >100 | - |
| Amphotericin B | 0.10±0.01a | nd | - |
| Camptothecin | nd | 0.74±0.09a | - |
The letters (a–e) indicate significant differences between the samples according to the Duncan Test (p<0.05)