Table 2.

Frequency of IgG subclass deficiency according to the presence or absence of associated hypogammaglobulinemia in the merged cohort (MACRO and STATCOPE cohorts combined)

IgG abnormality	Merged Cohort (n = 1629)
IgG1 deficiency – no. (%)	74 (4.5%)
With hypogammaglobulinemia – no. (%)	72 (4.4%)
No hypogammaglobulinemia – no. (%)	2 (0.1%)
IgG2 deficiency – no. (%)	93 (5.7%)
With hypogammaglobulinemia – no. (%)	69 (4.2%)
No hypogammaglobulinemia – no. (%)	24 (1.5%)
IgG3 deficiency – no. (%)	124 (7.6%)
With hypogammaglobulinemia – no. (%)	72 (4.4%)
No hypogammaglobulinemia – no. (%)	52 (3.2%)
IgG4 deficiency – no. (%)	114 (7.0%)
With hypogammaglobulinemia – no. (%)	73 (4.5%)
No hypogammaglobulinemia – no. (%)	41 (2.5%)
One or more IgG subclass deficiency – no. (%)	306 (18.8%)
With hypogammaglobulinemia – no. (%)	197 (12.1%)
No hypogammaglobulinemia – no. (%)	109 (6.7%)
Two IgG subclass deficiencies combined – no. (%)	47 (2.9%)
With hypogammaglobulinemia – no. (%)	37 (2.3%)
No hypogammaglobulinemia – no. (%)	10 (0.6%)
Three IgG subclass deficiencies combined – no. (%)a	20 (1.2%)
All IgG subclass deficiencies combined – no. (%)a	4 (0.2%)

The normal range for IgG levels in adults used in this analysis were: IgG1, 2.8–8.0 g/L; IgG2, 1.15–5.70 g/L; IgG3, 0.24–1.25 g/L; IgG4, 0.052–1.250 g/L; total IgG, 7.0–16.0 g/L. ^aAll participants were diagnosed with hypogammaglobulinemia (total IgG < 7.0 g/L).