Table 1.
Burkholderia Eradication Protocol
| Medication | Dosing | Frequency | Route | Bacteria Targeted | |
|---|---|---|---|---|---|
| Induction Period (21 Days): | Tobramycin | 6 mg/kg (per kinetics) | Daily | IV | PsA, Bcc |
| Ceftazidime | 2 g | Every 8 h | IV | PsA, Bcc | |
| Trimethoprim/Sulfamethoxazole | 800/160 mg | Twice Daily | Oral | Bcc | |
| Tobramycin inhaleda | 300 mg | Twice Daily | Nebulized | PsA, Bcc | |
| Azithromycin | 250 mg | Daily | Oral | Anti-inflammatory | |
| Consolidation Period (2 months): | Trimethoprim/Sulfamethoxazole | 800/160 mg | Twice daily | Oral | Bcc |
| Tobramycin inhaleda | 300 mg | Twice daily | Nebulized | PsA, Bcc | |
| Azithromycin | 250 mg | Daily | Oral | Anti-inflammatory |
aAlternative- TIP (tobramycin dry powder for inhalation, 4 caps (28 mg/cap)) every 12 h