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Schematic representation of the metabolism of Ang II to Ang III by aminopeptidase A (APA) and Ang III to Ang IV by aminopeptidase N (APN) with peptide sequences. Ang III is the major endogenous AT2R agonist inducing natriuresis in rodents. Ang II: angiotensin II; Ang III: angiotensin III; AT2R: angiotensin subtype 2 receptor.
