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. Author manuscript; available in PMC: 2019 Jan 19.
Published in final edited form as: Org Lett. 2018 Jan 5;20(2):357–360. doi: 10.1021/acs.orglett.7b03591

Scheme 3. Scope of Activated Tertiary Alkyl Halidesa,b.

Scheme 3

aConditions II: 1 (0.25 mmol), 2 (5 mmol), Pd(OAc)2 (0.025 mmol), Xantphos (0.05 mmol), Cs2CO3 (0.5 mmol), PhH (0.5 mL), rt, 12 h. bConditions III: 1a (0.375 mmol), 2 (0.25 mmol), Xantphos Pd G3 (0.025 mmol), iPr2NEt (0.5 mmol), PhH (0.5 mL), 40 °C, 12 h. c1 (0.25 mmol) and 2 (0.5 mmol) were used. d5 mol % of Xantphos Pd G3 was used. eAlkyl bromide was used. fReaction required 45 °C and 24 h for completion. gYield for a 1 mmol scale reaction.