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. Author manuscript; available in PMC: 2018 Jun 15.
Published in final edited form as: Bioorg Med Chem. 2017 Apr 8;25(12):3223–3234. doi: 10.1016/j.bmc.2017.04.008

Fig. 2.

Fig. 2

The SYBYL calculated distance between the Q-site predicted binding sites residing proximal to the nucleotide binding domains in the non-ATP bound state (apo) of MDR-1, based on the Mus musculus P-gp coordinates.12,13 B, C, D, calculated distances for n = 2, 3 and 5, tethered dimers, respectively, in energy minimized conformations.