Vacuolar transport of secondary products and xenobiotics. A, Vacuolar pumps (red) and transporters (blue) known to be implicated in delivering or releasing secondary plant products and xenobiotics. B, Phenotypes of a wild-type (left) and a mutant (right) maize in the putative anthocyanin transporter ZmMRP3 (Goodman et al., 2004). C, Transport of anthocyanins requires glutathione (Francisco et al., 2013). D, Color of wild-type (WT), tt12 mutant, corresponding to a mutation in a MATE transporter, and complemented Arabidopsis seeds (Debeaujon et al., 2001). E, Silencing of the vacuolar NPF in Catharathus roseus plants leads to a high accumulation of strictosidine (peak framed in red; Payne et al., 2017).