Figure 2. Adenosine hyperpolarizes mitral cells by A₁ receptor activation.

A, 100 μm adenosine (Ado) leads to a hyperpolarization of mitral cells in wild‐type (control) but not in A₁ knockout mice (A₁KO). B, the A₁ receptor agonist N ⁶‐CPA (1 μm) mimics the effect of adenosine. C, the A₁‐selective antagonist DPCPX (1 μm) inhibited the adenosine‐evoked hyperpolarization. D, summary of the pharmacological investigation of the adenosine‐induced membrane potential shift. n.s., not significant. E, no significant difference (n.s.) in the adenosine‐evoked hyperpolarization was found between mitral cells with intact apical dendrite and mitral cells with cut apical dendrite.