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. 2018 Jan 24;596(4):717–733. doi: 10.1113/JP275503

Figure 3. Adenosine increases the membrane conductance.

Figure 3

A, membrane conductance was measured by hyperpolarizing voltage steps of −10 mV in presence of TTX (1 μm), NBQX (10 μm), d‐APV (50 μm) and gabazine (10 μm). B and C, application of 100 μm adenosine increased the membrane conductance. D, adenosine‐induced hyperpolarization as measured in whole‐cell current‐clamp configuration using pipette solutions with different chloride concentrations, resulting in calculated chloride reversal potentials (E Cl) of −61 and −16 mV, respectively. E, the adenosine‐evoked hyperpolarization was independent of the chloride reversal potential (n.s., not significant).