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. 2018 Jan 24;596(4):717–733. doi: 10.1113/JP275503

Figure 5. Adenosine activates non‐canonical potassium channels.

Figure 5

A–D, effect of 1 mm Ba2+ (A), 10 mm 4‐AP (B), 10 mm TEA (C) and 500 μm bupivacaine (D) on the adenosine‐evoked hyperpolarization. E, effects of blockers of inwardly rectifying (1 mm Ba2+), canonical voltage‐gated (10 mm 4‐AP, 10 mm TEA), two‐pore domain (500 μm bupivacaine), erg (10 μm E‐4031), ‘M’‐current (20 μm XE 991) and calcium‐activated (1 μm TRAM‐34, 1 μm UCL 1684) potassium channels. Only bupivacaine significantly reduced the amplitude of adenosine‐evoked hyperpolarization. All recordings were performed in the presence of 1 μm TTX. n.s., not significant.