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. 2017 Dec 18;596(4):667–689. doi: 10.1113/JP274861

Figure 5. LD and VD show differences with respect to dendritic membrane non‐linearity.

Figure 5

A, to reveal voltage‐dependent membrane properties in the VD and LD, we injected current ramps (I nA) in the soma when recording membrane voltage (Vm) in the LD or VD with a second electrode (Aa). Ab, putative changes in resistance during membrane depolarizations where analysed in voltage current plots by comparing the I–V slopes close to RMP (slope 1 shaded region) and for depolarizations 2–3 mV below threshold (slope 2 shaded region). The sample traces show the response recorded in LD, 172 μm away from soma with a values of 34  and 43 kΩ for slope 1 and slope 2, respectively. Dashed line indicates a linear fit to slope 1. B, box plot of slope 2/slope 1 ratios for the VD (red, n = 4) and LD (blue, n = 8) indicate a higher value for the former (* P = 0.02). Dashed line indicates a hypothetical linear response of the membrane. [Color figure can be viewed at wileyonlinelibrary.com]