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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Shock. 2018 Mar;49(3):288–294. doi: 10.1097/SHK.0000000000000995

Figure 6.

Figure 6

Knockdown of Rab5 in endothelial cells attenuates the endothelial activation response after treatment with RBC-derived MPs. Nonsense (NS) siRNA was used as a control for all experiments. (A) Cells treated with NS siRNA, then MPs demonstrate increased ICAM and E-selectin expression. This effect was attenuated in Rab5-knockdown cells. (B) Quantification of adhesion molecule upregulation data. (C) NS cells treated with MPs also demonstrated increased concentrations of IL-6 as compared to Rab5-knockdown cells. This effect was inhibited in cells treated with Rab5 siRNA, then MPs. *p<0.05, vehicle vs MP; #p<0.05, NS+MP vs Rab5+MP.