Table 1. Morphometric data of HF and age-matched control rabbits.
Heart failure was induced in 10 rabbits and progression was assesed periodically by echocardiography. Data of HF rabbits at the time when cardiac myocytes were isolated are compared to 5 age-matched healthy control rabbits.
Age-matched control | HF | |
---|---|---|
Age (years) | 2.40±0.17 | 2.46±0.35n.s. |
Body weight (kg) | 3.99±0.14 | 3.98±0.13n.s |
Heart weight (g) | 10.46±0.59 | 21.86±2.54*** |
HW/BW (g/kg) | 2.63±0.15 | 5.52±0.71** |
Lung weight (g) | 13.86±0.25 | 18.94±1.16** |
LW/BW (g/kg) | 3.49±0.12 | 4.95±0.21** |
LVESD (cm) | 1.08±0.07 | 1.63±0.11*** |
LVEDD (cm) | 1.71±0.07 | 2.29±0.09*** |
FS (%) | 36.70±2.02 | 28.39±1.13* |
All data represent mean±SEM. Unpaired, two-tailed Student’s t test;
p<0.05,
p<0.01,
p<0.001.
(HW/BW, heart weight–to–body weight ratio; LW/BW, lung weight–to–body weight ratio LVESD, left ventricular end-systolic diameter; LVEDD, left ventricular end-diastolic diameter; FS, fractional shortening calculated as FS=(LVEDD-LVESD)/LVEDD*100)