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. Author manuscript; available in PMC: 2018 Mar 15.
Published in final edited form as: ACS Chem Neurosci. 2016 Nov 23;8(3):486–500. doi: 10.1021/acschemneuro.6b00221

Figure 1.

Figure 1

Functional screening of SK609 and its analogues for their ability to selectively phosphorylate ERK1/2. Functional screening of SK609 and all analogues on CHO-D2R or CHO-D3R cells with vehicle or test compounds using ERK1/2 phosphorylation as end point as described in Methods. Representative Western blot (one of three independent experiments) of ERK1/2 phosphorylation (p-ERK1/2) induced by 1 μM of dopamine (DA), PD128907 (PD), SK609, or its analogues for 5 min. SK609 and its analogues are represented by just their numerical part; 609S represents the hydrochloride salt of SK609 and L1 and L2 are the Lichtenberger compounds. DMSO, dimethyl sulfoxide; VC, vitamin C.