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. Author manuscript; available in PMC: 2018 Mar 15.
Published in final edited form as: ACS Chem Neurosci. 2016 Nov 23;8(3):486–500. doi: 10.1021/acschemneuro.6b00221

Table 3.

Ki Values (nM) of SK609 and Its Analogue or Reference Compound Binding to the CHO-D3Ra

compd Ki (nM) to CHO-hD3
Ki-H Ki-L
DA 9.9 ± 4.4 246 ± 105
PD128907 3.7 ± 1.6 14.6 ± 3.6
609 283 ± 30 4955 ± 1314
608 103 ± 25 1029 ± 45
32 1109 ± 310 9504 ± 1551
52 1758 ± 901 9293 ± 1015
213 3708 ± 1003 8082 ± 1185
232 7008 ± 1850 7705 ± 1987
a

Competitive inhibition by SK609 and its analogues or reference compounds of [3H]methylspiperone binding to D3R was conducted. The competition curves were fitted by two-site analysis and its high-affinity Ki values (Ki-H) and low-affinity Ki values (Ki-L) were determined using the Prism program. Each value represents mean ± SEM of three experiments performed in duplicate.