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. Author manuscript; available in PMC: 2019 Feb 12.
Published in final edited form as: Cancer Cell. 2018 Feb 12;33(2):309–321.e5. doi: 10.1016/j.ccell.2018.01.008

Figure 2. Distinct loci-level methylation changes in early transformation compared to senescence.

Figure 2

(A) A phyloepigenetic tree was constructed to infer the evolutionary relationships of replicative cellular senescence lineage and immortalization-transformation lineage. Promoter CpGI probes were used.

(B) Heatmap shows methylation levels of promoter CpGI probes with Standard Deviation (SD) ≥ 0.15 across all samples (top variable probes).

(C) Smoothscatterplot shows comparison of methylation level (β value) between Sen and Near_Sen at promoter CpGIs. Scatterplot shows comparison of methylation deviation (Δβ value) of Near_Sen and Sen from EP at promoter CpGIs. Pearson’s correlation coefficient is shown. Diagonal represents identity line. The 2nd replicate serves as representative.

(D) Same analysis as those in Figure 2C, but compared Sen with hTERT.

(E) Same analysis as those in Figure 2C, but compared Sen with HRAS.

See also Figure S2.