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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Curr Opin Genet Dev. 2017 Jul 7;46:83–94. doi: 10.1016/j.gde.2017.06.004

Figure 3. Functional diversity of the CAF-1 complex and its influence on chromatin structure and histone modifications.

Figure 3

Depiction of CAF-1 complex composition, highlighting its function as (1) a replication-dependent histone chaperone via its interaction with PCNA and association with H3/H4 histone tetramers, (2) heterochromatin silencing factor via recruitment of silencing complexes such as HP1/Sedtb1, which influence H3K9me3 deposition and LSD1 and HDAC, which influence erasure of H3K4 di- and tri-methylation and H3 acetylation.