Table 2.

ROC curve analysis of blood and urinary biomarkers.

Biomarker	AUROC	Std. error	95% confidence interval	P value
Blood/conventional
BUN	0.6368	0.07728	0.4853–0.7882	0.0486
sCre	0.5692	0.06723	0.4375–0.701	0.3385
Urinary protein
IP-10	0.8015	0.0567	0.6903–0.9126	<0.0001
Renin	0.7334	0.07199	0.5923–0.8745	0.0013
NGAL	0.6962	0.0711	0.5569–0.8356	0.0054
B2M	0.6251	0.07968	0.4689–0.7813	0.0847
Clusterin	0.6062	0.07064	0.4677–0.7446	0.1333
Osteopontin	0.5827	0.07393	0.4378–0.7276	0.2422
KIM-1	0.5771	0.07733	0.4256–0.7287	0.2879
Cystatin C	0.5683	0.07173	0.4277–0.7089	0.3326
TIMP-1*	0.5833	0.1099	0.3679–0.7988	0.4516
VEGF	0.5236	0.07896	0.3689–0.6784	0.7506
EGF	0.5087	0.07218	0.3672–0.6502	0.902
Urinary miRNA
miR-685	0.8234	0.05461	0.7163–0.9304	0.0001
miR-138	0.8108	0.06258	0.6882–0.9335	0.0004
miR-218	0.7891	0.05807	0.6752–0.9029	0.0007
miR-221	0.769	0.06628	0.6391–0.8989	0.0014
miR-680	0.7649	0.06285	0.6418–0.8881	0.0017
miR-320	0.7595	0.06793	0.6264–0.8927	0.0021
miR-130a	0.7486	0.06136	0.6284–0.8689	0.0032
miR-151-3p	0.7473	0.07087	0.6084–0.8862	0.0034
miR-328	0.7351	0.07534	0.5874–0.8827	0.0054
miR-152	0.7133	0.06969	0.5767–0.8499	0.0115

AUROC: area under the ROC; BUN: blood urea nitrogen; B2M: β2-microglubulin; EGF: epidermal growth factor; IP-10: interferon gamma-induced protein 10; KIM-1: kidney injury molecule-1 (KIM-1), albumin; NGAL: neutrophil gelatinase-associated lipocalin; ROC: receiver-operating characteristic; TIMP-1: TIMP metalloprotease inhibitor 1; VEGF: vascular endothelial growth factor.

Within each biomarker category, markers are sorted by AUROC value from highest to lowest.

*Several values for TIMP-1 in both the vehicle- and cisplatin-treated mice were below the lower limit of quantification; therefore, these data should be interpreted with caution.