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. 2018 Feb 15;13(2):e0192404. doi: 10.1371/journal.pone.0192404

Fig 5. Proposed working model for the inhibitory effect of Euglena extract on adipocyte-differentiation.

Fig 5

In the early phase of adipogenesis, CREB activated by IBMX induces the expression of C/EBPβ, and C/EBPδ is induced by DEX [12, 13, 20]. Another transcription factor, SREBP1c, is induced by insulin [17]. These transcription factors induce PPARγ, which also induces C/EBPα. Cross-regulation exists between PPARγ and C/EBPα and is considered a key component of transcriptional control for adipogenic genes [14]. Our observations indicate that Euglena extract inhibits the gene expression of CREB and SREBP1c, resulting in the downregulation of PPARγ and C/EBPα and inhibition of adipocyte-differentiation (Figs 2 and 3).