Table 4.
Biomarker ROC and best cutoff point to predict Th2-high or Th2-low patterns
| Biomarker | ROC | Value |
|---|---|---|
| IL-6 | AUC (95% CI) | 0.550 (0.479–0.620) |
| Best cutoff (pg/mL) | NA | |
| IL-8 | AUC (95% CI) | 0.507 (0.434–0.579) |
| Best cutoff (pg/mL) | NA | |
| TNF-α | AUC (95% CI) | 0.570 (0.499–0.641) |
| Best cutoff (pg/mL) | 4.04 | |
| IL-13 | AUC (95% CI) | 0.552 (0.482–0.623) |
| Best cutoff (pg/mL) | NA | |
| IL-5 | AUC (95% CI) | 0.582 (0.512–0.652) |
| Best cutoff (pg/mL) | 1.79 | |
| Periostin | AUC (95% CI) | 0.602 (0.528–0.677) |
| Best cutoff (IU/mL) | 35.2 | |
| IL-5 + IL-13 | AUC (95% CI) | 0.579 (0.508–0.650) |
| IL-5 + IL-13 + IL-8 | AUC (95% CI) | 0.593 (0.523–0.662) |
| IL-13/IL-8 | AUC (95% CI) | 0.549 (0.479–0.619) |
| IL-5/IL-8 | AUC (95% CI) | 0.586 (0.517–0.654) |
| Best cutoff | 0.15 | |
| IL-17 | AUC (95% CI) | 0.556 (0.486–0.626) |
| Best cutoff (pg/mL) | NA |
Abbreviations: AUC, area under the ROC; CI, confidence interval; NA, not applicable; ROC, receiver operating curve; TNF-α, tumor necrosis factor-α.