Fig 3. The complete Ca²⁺-CaM-CaMKII network.

(A) Species are represented by vertices. Green edges mark the preferred pathway. The back layer (Layer 1, blue) represents interactions between Ca²⁺ and CaM. The front layer (Layer 2, yellow) represents interactions between Ca²⁺ and CaM attached to a CaMKII subunit. Note these interactions are bidirectional. (B) Molecule numbers of various CaM states with 5 Hz Ca²⁺ influx. Plots of Layer 1 and Layer 2 are displayed to provide a view of the preferred path. The species marked with green triangles constitute part of the preferred pathway. Note that only panel N0C0 in Layer 1 is on a scale from 0 to 6000. All the other panels have a scale from 0 to 1500.