Fig 9. Effects of CaM availability and Ca2+ diffusion on frequency dependence.
(A) With 3× Ca2+ influx, phosphorylated CaMKII subunits in the presence of 5 Hz (blue) and 10 Hz (black) Ca2+ input. (B) The same as in A except that the total CaM available in the system is reduced from 5 μm to 2.5 μm. (C) The same as in A except that Ca2+ diffusion is slowed to 1.1 × 10−6 cm2 s−1. (D) The same as in A except that 2× Ca2+ influx is provided. (E) The same as in D except that the total CaM available in the system is reduced from 5 μm to 2.5 μm. (F) The same as in D except with both slowed Ca2+ diffusion and reduced the amount of CaM.