Fig. 2.
(A) Comparison of dose-dependent induction of acute airway inflammation in mice by purified LOS-agg or intact bacteria (NMB) measured 4 h after i.n. administration. The doses of LOS-agg and of intact bacteria are normalized based on their LOS content (see legend to Fig. 1). (B) Induction of accumulation of PMN recovered in BAL 4 h after instillation of 2 x 107 meningococci (containing 300 ng LOS) is MD-2-dependent. Data shown represent the mean ± SEM of results obtained from groups of 5 (A) or 4 (B) mice and represent the results of one of two similar experiments. Mice exposed to vehicle (PBS) alone had < 1x103 PMN in recovered BAL.