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. 2017 Nov 9;9(5):5517–5528. doi: 10.18632/oncotarget.22342

Figure 5. Anti-miR-17 therapy leads to de-repression of miR-17 targets.

Figure 5

A. Volcano plot shows genes differentially expressed with anti-miR-17 treatment. Genes colored in blue represent the differentially expressed genes. B. Heat map of the top 20 genes differentially expressed upon treatment with control versus anti-miR-17 oligonucleotide. C. De-repression of several known targets of miR-17 was seen including E2f1, Tgfbr2 and Cdkna1 in tumors treated with anti-miR-17 therapy. D. Pathway analysis of differentially expressed genes revealed that enhancement of cell death and inhibition of cellular proliferation (p=1.9X10-5) were key functional changes induced by anti-miR17 therapy. The lines in orange represent inhibition and the lines in blue show activation.